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N-acetyl-cysteine (NAC), a derivative of amino acid L-cysteine, is currently used mainly as an antioxidant [15]

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In addition, iCAFs inhibited several hallmark pathways, such as the TGF-beta signaling, WNT signaling, Hippo signaling, and mTOR signaling pathways, suggesting the transition of iCAFs to an antitumor phenotype (Figure S10F)

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