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In the POLLUX clinical trial, patients with relapsed or refractory multiple myeloma who received the combination of the anti-CD38 antibody daratumumab with lenalidomide and dexamethasone had significantly prolonged progression-free survival (PFS) relative to those who received lenalidomide and dexamethasone alone
The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further
Among 38,097 patients the mean number of intramuscular injections per patient was 8.81 per year
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