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This activation, in turn, results in the degradation of the mutated form of tumor protein P53 (TP53), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an inhibitor of nuclear factor kappa B alpha (IB-), and HK2 protein, leading to metabolic catastrophe and cell death in AML cells [57, 58]

Ischemic lesions involving this region have been associated with an increased risk of cardiac complications ( Beyond autonomic regulation, the insula integrates autonomic, neuroendocrine, and inflammatory viscerosensory feedback into subjective emotional states (interoception) ( The medial prefrontal cortex, located in the medial frontal lobe, and orbitofrontal cortex, situated on the ventral surface of the frontal lobes, are involved in the cognitive appraisal and regulation of emotional responses