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UV rays trigger the production of melanin

The right panel describes strategies for managing peak-dose dyskinesias (involuntary movements during ON periods), which include reducing individual levodopa doses to lower the dopaminergic load or adding Amantadine to suppress the dyskinesia

Targeting to and/or across blood-tissue barriers In another aspect of the invention, a method of targeted drug delivery of an effective amount of an agent, or a pharmaceutical acceptable carrier comprising an agent, to a target site that is protected by a specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes, is provided wherein: a) the agent or the pharmaceutical acceptable carrier is conjugated to a ligand, that facilitates the specific binding to and internalization by an internalizing GSH uptake receptor of the target site, thereby forming the conjugate as defined above

Carfrae, L