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doi:10.1371/journal.pone.0086617
Research also demonstrated that the combination of lipid-lowering drugs and use of new drug classes such as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can reduce LDL-C levels by 50%70%, resulting in further reduction in major adverse cardiovascular events (MACE) based on statin therapy
TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes
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