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Leptin and prostate cancer

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For instance, although PC3, BT-549, and HOP-92 cells exhibit some of the highest labile intracellular Cu levels, exposure to the TC-Py ligand resulted in low micromolar GI 50 values (14.45, 12.59, and 1.20 M, respectively), comparable to those observed in cell lines with relatively low labile Cu, such as MCF7, T47D, and OVCAR-8 (9.12, 6.03, and 2.69 M, respectively)

Since astrocytes contribute to both energy and antioxidant homeostasis in neurons it is likely that dopaminergic neurons are more susceptible to oxidative stress and energy failure due to the low number of astrocytes in the SNpc compared to other brain areas