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54,197 Long-term perturbation of gut microbiome using antibiotic cocktail resulted in reduced A deposition, reduced plaque-localized microglia and altered transcriptional profile of microglia (increased homeostatic microglial genes and decreased MGnD genes) in 7-week-old male APP/PS1-21 mice

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In addition, reduced activity in the prefrontal cortex was associated with increased emotional reactivity in the amygdala, emphasizing its regulatory role [27,28]

Library preparation and RNA sequencing was performed by Novogene