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Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1084 - ESOC25-1890 The safety and effiCacy of HIbernation-Like therapy combining recanaLization in ischemic stroke(CHILL-1): a phase 1, dose-escalation study Shuaili Xu 1 , Qi Wang 2 , Di Wu 3 , Xunming Ji 2 1 Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China, 2 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China, 3 China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China Background and Aims: Torpor or hibernation is characterized as a status of hypothermia and hypometabolism, helping animals survive harsh environment

While Retatrutide naturally reduces caloric intake through appetite suppression, deliberately eating too little accelerates muscle loss even with anabolic support

Somewhat unexpected was that M1 high tumors also demonstrated elevation of unfavorable immune activity such as Leukocyte Fraction and TGF-beta Response at the same time (Fig

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