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In this contribution, we constructed a BSO-based hypertoxic self-assembled peptide derivative Nap- D F D FY-CS-DEVD-BSO (abbreviated as NSBSO) with dual functions of GSH depletion and biosynthesis inhibition for tumor ferroptosis and pyroptosis (Scheme 1)

Going the extra (Synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases

Design and synthesis of isothiocyanate-containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH-Deficient prostate cancer cells

In PD cell and mouse models, celastrol plays a neuroprotective role by activating mitochondrial autophagy and inhibiting DA neuron loss (176)