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& Dimitriou, G

In the recent large HFrEF trial, a higher dosage was employed: four 0.3 g capsules three times daily (total 3.6 g/day) alongside standard therapy (Leung et al., 2021
The gene dosage hypothesis states that the increased dosage of Chr21 genes is the direct cause of the phenotypical alterations of the DS population

Holding the B12 in your mouth for at least 90 seconds is good and the longer you can leave it in your mouth, the better for sublingual absorption (as opposed to gut absorption)
