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6 , eaay6324 (2020)

Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity

As an oral supplement, glutathione is popular and widely available

Although these direct antioxidant effects are observable in vitro, their significance in vivo appears limited, stemming from low plasma concentrations of NAC and the prevalence of more abundant endogenous antioxidants such as GSH, ascorbate, and antioxidant enzymes (e.g., SODs, GPs, CAT) [6,38,39]
