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Description
showed that AROS is indeed a SIRT1 agonist through several in vitro SIRT1 activity assays (68)

It has inherent antioxidative activity as it can donate a hydrogen ion from its chromanol ring to scavenge lipid peroxyl radicals [6,7,8]
It also neutralizes hydroperoxide effects, such as cytokine signal and apoptosis, and also has an important role in the human immunodeficiency virus (HIV) infection

Melatonin is a neurotransmitter whose production is highly correlated with time of day