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Our findings reveal a previously unidentified role of IRE1 to regulate ferroptosis and suggests inhibition of IRE1 as a promising therapeutic strategy to mitigate ferroptosis-associated pathological conditions
What is missing is human RCT data showing the combination outperforms either compound alone

MitoTEMPO is a nitroxide tethered to a positively charged triphenylphosphonium group through an alkyl side chain

Produced naturally by the body, glutathione is widely sold as a supplement
