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An increase in temperature within PDAC tumor tissue drives alterations in lipid metabolism, including a decrease in PUFAs such as phosphatidylcholine plasmalogen (PC-P), attenuating lipid peroxidation and ferroptosis, and further drives gemcitabine resistance in PDAC through the p38-MAPK pathway [154]

Repurposing existing anti-inflammatory and metabolic drugs may be a viable approach to treat pain and metabolic dysfunction in PCOS

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P-450 2E1 is induced by alcohol consumption and possibly starvation, and glutathione depletion can occur due to the inadequate nutrition occurring in chronic alcohol use or in starvation