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If harm at high doses is established then perhaps B12 has a therapeutic range, outside of which it causes harm
Long-term human safety data for Dihexa is limited

These studies showed that the peptide can reduce the harmful effects of the senescence associated secretory phenotype (SASP)

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Spruijt CG, Luijsterburg MS, Menafra R, Lindeboom RGH, Jansen PWTC, Edupuganti RR, et al