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All described studies evaluating small intestinal permeability used a 5 or 6 h urinary collection to assess small intestinal permeability, which may have confounded the results since a large amount of the sugars were probably already localized in the colon by the end of the urine collection (73, 74)

However, detailed insights into the interaction mechanisms, preferred binding locations, and conformational changes in BSA upon binding TMAO are still unclear

On the other hand, the sharply delayed gastric emptying caused by the quick rise in plasma levels of these short-acting receptor agonists significantly reduces postprandial glucose excursions after breakfast (for exenatide and lixisenatide) and before dinner (for exenatide) (30)