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MLN4924, a small molecule inhibitor of neddylation, increases glutamine uptake in breast cancer cells by inactivating the CRL3-SPOP E3 ligase, leading to the ASCT2 upregulation
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10.1038/s41420-020-00396-7 [DOI] [PMC free article] [PubMed] [Google Scholar] 130.Teng, Y.-C
Consequently, the mitochondrial membrane potential collapses and cytochrome c is released, resulting in cell apoptosis
