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Daily use provides better results compared to irregular intake
Synthesis of adefovir prodrug (adefovir dipivoxil, Bis(POM)-PMEA) proceeds from adefovir by the action of chloromethyl pivalate (Figure 3) (Starrett et al., 1992)

Experimental studies have shown that treating cortical neurons with ALC can counter the neurotoxic effects of amyloid A25-35 fragment [80]

Traumatic brain injury (TBI) is a major pediatric health problem with a rate of 500,000 per year in the US and leading to ~ 3000 pediatric deaths [134, 148]
