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Berberine as a multi-target therapeutic agent for obesity: from pharmacological mechanisms to clinical evidence
ALDH1A1, ALDH1A2, ALDH1A3, ALDH1A7 and ALDH8A1, catalyze the irreversible conversion of retinaldehyde to retinoic acid (RA), which plays critical role in developmental process by modulating retinoid signaling [1, 36]
The repeated NAD + /NADH conversions also suggest much more complicated and repeated oxidation/reduction responses in brain cortex during neuronal and astrocytic activities than previously considered (e.g., Kasischke et al., 2004)
doi: 10.1177/1758834015616934
