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The common problems are acute mountain sickness (AMS), insomnia, lack of appetite, tiredness, lethargy, upset stomach, disinclination to work, bone and muscle degradation, high-altitude pulmonary edema (HAPE), high-altitude cerebral edema (HACE), and all resulted in decrease in physical and mental performance in unacclimatized individuals [48]

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Transcriptome sequencing data were compared with Drosophila genome annotation release 6.37 using BWA software, genome sequence was divided into 395,891 intervals of different lengths according to methylated GATC sites