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Among other effects (section 7.2.1), degeneration of testes tubules was observed at the higher exposure level in guinea-pigs, while at 370 mg/m 3 , there was a decrease in the relative weights of testes in rats and guinea-pigs, which was not statistically significant (Hollingsworth et al., 1956)

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In the TCA, succinate is oxidized to fumarate and then hydrated to malate through the activity of two enzymes, succinate dehydrogenase, and fumarase