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All Aspergillus allergens appear to activate a Type I hypersensitivity response in sensitized patients with production of high affinity IgG and IgE antibodies.232 In immunocompromised patients with debilitated innate immune responses, these allergenic compounds can increase the risk associated with aspergillosis because they may redirect the immune response to the fungus by the activation of Th2 lymphocytes, a response that does not seem to be efficient in eliminating this fungus.108 Some of these allergens have been studied for their usefulness for diagnosis (see Allergome1 and Table 7)

For all cell collections, genomic DNA isolation, PCR amplification of the sgRNA sequences, amplicon purification, and next-generation paired-end sequencing were performed according to Callow et al

NOX4 is an enzyme responsible for producing reactive oxygen species (ROS) that contribute to oxidative stress in cells

10.1016/j.bcp.2024.116205 57 LiuD.JinX.ZhangC.ShangY