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10.1016/j.freeradbiomed.2015.06.019 [DOI] [PubMed] [Google Scholar] 235.da Costa RM, Rodrigues D, Pereira CA, Silva JF, Alves JV, Lobato NS, et al
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changes in the ratio of NADH to NAD + (i.e., the cells redox state)
In addition, dose-limiting toxicities, particularly hematologic and gastrointestinal adverse effects, continue to constrain broader clinical applications
