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None had a placebo control group

31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%

Maternal vitamin B 12 status during pregnancy and its association with outcomes of pregnancy and health of the offspring: a systematic review and implications for policy in IndiaFront Endocrinol (Lausanne)2021;12:619176

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