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Description
The intermediate form of the enzyme is further reduced by the formation of an intra-molecular disulfide bond between the two active site cysteines, leaving the enzyme in an oxidized form, from which the vicinal thiols are regenerated by the FAD(H)-intermediated hydride transfer from NAD(P)H

10.1016/j.sjbs.2013.06.002 40 SorkhehK.ShiranB.KhodambashiM.RouhiV.MosaveiS.SofoA

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The NRG CC001 trial established that hippocampal-avoidance WBRT (HA-WBRT) combined with memantine better preserves NCF and quality of life compared to conventional WBRT (32, 33)
