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doi: 10.1111/jocd.13679

The mechanism involves clearance of senescent Leydig cells that secrete pro-inflammatory SASP factors (IL-1, IL-6, TGF-) which impair testosterone production in neighboring healthy cells

Psoriasis and systemic inflammatory markers The studies conducted for the definition of inflammatory process of psoriasis helped to perform the exact measurements for proinflammatory cytokines such as IL-1 and TNF-, adhesion molecules as intracellular adhesion molecule-1 (ICAM-1) and selectines, IL-6 and hepatic acute phase reactants as C reactive protein (CRP) [13, 14]

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