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Elmore, ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
Neuropathy is believed to result from pyridoxine neurotoxicity to dorsal root ganglia when plasma levels are excessively high
Pioneering clinical work has demonstrated the potential of this approach: in a landmark trial, a blind patient expressing ChrimsonR in RGCs regained partial light perception after training with engineered goggles that converted visual scenes into optogenetic stimuli [221]
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