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These are resident populations of T-cells that establish themselves in a specific site, such as the skin, and are removed from circulation, proliferating and expanding within the site and have extended lifespans, on the magnitude of years in humans

To further test the therapeutic effect of NAC on tendon repair, we established a rat model of Achilles tendon injury and found that NAC treatment promoted the remodeling of collagen fibers and expression of key factors for tendon repair, mitigating the severity of tendon injury in rats

Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, Serrat R, Vicente-Gutierrez C, Ioannidou C, et al

Co-stimulatory or co-inhibitory receptor Immune cell functions are regulated by co-inhibitory and co-stimulatory receptors