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Vacchi-Suzzi C, Viens L, Harrington JM, et al

The authors began with a quality assessment, finding that 14 out of 38 reviewed studies were of poor quality due to failure to control for one or more items on a list of confounding factors that can influence cytokine levels: age, subject activity level, BMI, gender, menstrual cycle stage, comorbid diseases, antidepressant use, or diurnal variation

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