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Since, 2014, the company Mannkind Cooperation received the US market approval for Afrezza, an inhaled insulin with improved PK/PD properties, but the pulmonary toxicity issue could not be ruled out after all [247]

Future developments may focus on enhanced recyclability and further energy optimization

These metabolites exhibit distinct pharmacological properties compared to parent THC, with 11-OH-THC reported to be more potent than THC, while THC-COOH is considered inactive but is often used as a plasma marker of cannabis consumption in drug tests [51,88]

Diabetes-induced biochemical changes in rat lens: Attenuation of cataractogenesis by pyruvate