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Specifically, one double-blind trial in 140 patients with chronic schizophrenia, described by the Cochrane Collaboration as a high quality trial that measured clinically-useful outcomes (Positive and Negative Syndrome Scale [PANSS] and Clinical Global Impression [CGI]) over a longer period of time [145], compared adjunctive NAC versus placebo [146]
Even a single amino acid substitution can dramatically alter the peptide's properties and render it ineffective
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