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2 IV Acetadote protects liver cells in 2 ways: It helps replenish glutathione It binds to and removes NAPQI Return to top The maximum adult therapeutic dose of acetaminophen is 4 grams/24 hours 3 The maximum dose for children less than 12 years is 75 mg/kg 4 Acute overdose is defined as ingestion of 150 mg/kg or 12 grams/24 hours 4 Four stages of acetaminophen overdose 5 Return to top When time is liver, timing is critical Treatment Recommendations The following recommendations are related to acute acetaminophen ingestion

Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schinina ME, Coccia R, Head E, Butterfield DA, Perluigi M 2014 Redox proteomics analysis of HNE-modified proteins in Down syndrome brain:clues for understanding the development of Alzheimer disease

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