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Accumulation of zinc in intracellular milieu has been found to be associated with the death of dopaminergic neurons whereas chelation of zinc reverses the effect (Tamano et al., 2019)
While glutathione synthesis is controlled by multiple factors, GCL is the main determinant, because the rate-limiting step is the cellular level of the amino acid cysteine
doi: 10.3390/ijms22189990 90 IsraelyanN.Del ColleA.LiZ.ParkY.XingA.JacobsenJ
Synergistic benefits have been observed with the coadministration of TQ and tacrolimus
