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Once inside, cystine is reduced to cysteine, a rate-limiting precursor for the synthesis of glutathione (GSH) ( reduces cystine uptake, impairs GSH synthesis, and consequently diminishes the cells ability to detoxify lipid peroxides, thereby facilitating the onset of ferroptosis (Liu et al., 2023

Data availability Computer code for LSA, parameter estimation, numerical simulations, and GSA with PRCC was implemented in and run with the programming and computation software MATLAB (MathWorks Inc., Natick, MA, USA)

NAC improves hepatic glutathione levels, reduces oxidative stress, improves insulin sensitivity, and supports detoxificationmaking it highly relevant in NAFLD/NASH management

Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial