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The nonparametric Mann-Whitney U test and the Kruskal-Wallis test were used to compare different group variables

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While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

After being taken up, Fe3+ is reduced to Fe2+ in endosomes by the six-transmembrane epithelial antigen of prostate 3 (STEAP3), and then it is transported into the cytosol and free mitochondrial iron pools by solute carrier family 11 member 2(SLC11A2) ( 2+ can cause excessive lipid ROS accumulation through the Fenton reaction and can increase to activate nonheme iron-based arachidonate lipoxygenases (ALOXs) and nicotinamide adenine dinucleotide phosphate oxidases (NOXs), thereby promoting destructive lipid peroxidation ( 2+ is the degradation of hemoglobin mediated by haem oxygenase 1 (HMOX1)