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The enzyme indole-2,3-dioxygenase 1 (IDO1) in the first committed step of the de novo synthesis pathway metabolizes tryptophan to the immunosuppressive metabolite kynurenine in the context of immune challenges [27,28,29]

Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats

Lagenaur LA, Sanders-Beer BE, Brichacek B, Pal R, Liu X, Liu Y, et al

185 In conclusion, the data suggest that CBD plays dual modulating roles in the induction of the brown phenotype, in addition to promoting lipid metabolism