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Further, male rats had increased mortality, while surviving females displayed a significant decrease in serum IGF-1 and nearly a doubling of infarct volume and sensorimotor deficits ( In addition to disruption of circadian rhythms by repeated phase shifts (jet lag), foundational science research has examined the role of circadian disruption by light at night in stroke outcome

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To confirm this, it would be beneficial to test whether an increase in miR-29c can reduce the elevated levels of ENPP2 in mouse metastatic melanoma models and suppress cancer progression in future studies