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These observations were corroborated by single-cell calcium imaging studies in slices of arcuate nuclei, demonstrating that GLP-1MK-801 inhibits the NMDA-induced intracellular calcium surge relative to GLP-1 alone (Extended Data Fig
In addition, 2.0 M Compound K (CK), a metabolite of ginsenoside produced by intestinal flora, increases the expression of Gcg and GLP-1 secretion and promotes L-cell differentiation under high-glucose conditions (50 mM) in NCI-H716 cells
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