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This limitation impacts the calculation of specificity for the combined biomarker and necessitates a cautious interpretation of the results

ZO-1, -2, and -3 have three PDZ domains and a guanylate kinase-like domain (GUK) (107)

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doi: 10.3389/fcell.2021.813668 Received 12 November 2021 Accepted 31 December 2021 Published 20 January 2022 Volume 9 - 2021 Edited by Chunying Li, Fourth Military Medical University, China Reviewed by Takashi Matsui, University of Hawaii, United States Weinan Guo, Fourth Military Medical University, China Xin Wei, Second Hospital of Anhui Medical University, China Updates Copyright 2022 Leng, Luo, Yu, Jia and Yu