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Description
Biochemical assessments measured oxidative stress markers [superoxide dismutase (SOD), catalase, and glutathione (GSH)], proinflammatory cytokines (TNF, IL-6, and IL-1), and brain monoamines [dopamine (DA) and acetylcholine (ACh)]
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Long-term studies in laboratory models suggest that sustained NNMT inhibition may reprogram cellular metabolism toward enhanced oxidative capacity and improved stress resistance
Plasma-derived exosomes were characterized, their uptake by PBMCs was visualized and consequent ROS generation was assessed in in-vitro co-culture
