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50 Comparing their data with ours, it is interesting to note that 33 out of 50 (66%) of our index cases developed T1D between 0.8 and 3.8 years and 15 (30%) between 4.1 and 6.5 years (Table 1)

These small organic solutes are known to alter the cellular environment by interfering with the solvent properties (Gekko and Timasheff, 1981)

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