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This can help avoid delays due to unmet expectations
In this way, MSCs could promote repair through the production of anti-inflammatory cytokines such as interleukin (IL)-10 and TGF- 39 in addition to the inhibition of pro-inflammatory cytokines (tumor necrosis factor-, interferon gamma (IFN-), and IL-1 ), which have been identified to be released in the brains of PD patients 40,41
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This cautious approach can be attributed to the historical context of Rimonabant, a previously promising anti-obesity agent withdrawn from the market in 2008 due to severe psychiatric side effects 26
