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Description
GLY I converts a highly cytotoxic metabolite methylglyoxal (MG) into S-lactoylglutathione (SLG) with the help of reduced glutathione (GSH) 3 .The SLG is further hydrolyzed into D-lactate by GLY II and GSH is recycled back into the system (Fig
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Therefore, thyroid dysfunction, including abnormalities in thyroid hormone synthesis and the emergence of autoimmune thyroid conditions such as Graves disease and Hashimotos thyroiditis, has been linked to Se deficiency

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