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The catabolism of all five substrates yields propionyl-CoA which is converted to the TCA cycle intermediate, succinyl-CoA, by a series of three reactions catalyzed by propionyl-CoA carboxylase, methylmalonyl-CoA epimerase, and methylmalonyl-CoA mutase

[Link] A mechanism for the antidepressant property of ALCAR is proposed, and the novelty of the possible role of ARTN in depression is suggested. Soczynska, J, et al, Acetyl-L-carnitine and -lipoic acid: possible neurotherapeutic agents for mood disorders? in Expert Opinions on Investigational Drugs , Volume 17, Issue 6, 2008, pp 827 - 843

ALA functions both as a coenzyme for mitochondrial enzymes and as an ideal antioxidant

C., Gambaro, G., Taylor, E