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Recent elegant kinetic research on loss-of-functions (LOF) apoCIII in humans has provided striking proof ( Figure 5A , in controls, CM residence time per particle was 30 min, and turnover was 50 pools per day

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Even nanoparticles that do not rely on amines, such as poly-(lactide- co -glycolide) (PLGA) polymers, endosomal escape takes place during pH change due to a selective reversal of the particle's surface (Panyam et al., 2002)
