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10.1007/s00404-012-2632-8 41

While this patient's progressive renal deterioration makes blood pressure control difficult, resistant hypertension is managed by optimizing multidrug antihypertensive regimens and volume status, not by initiating emergent hemodialysis

Therapeutic potential of madecassoside in transgenic mice of amyotrophic lateral sclerosis

What you want to avoid is dosing immediately before or during the meal, which creates direct receptor competition at the moment IGF-1 LR3 is trying to bind
