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22 Xanax is licensed to treat: Acute generalized anxiety disorder in adults Acute panic disorder in adults, with or without agoraphobia Off-label uses include: Depression Insomnia PMS Substance Use disorders Seizures Alcohol withdrawal Epilepsy Muscle spasms Catatonia that presents in Bipolar and schizophrenia While Xanax can very quickly dampen anxiety or insomnia for a brief period, and is effective at aborting an acute seizure, drug tolerance sets in rapidly