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10.1016/j.immuni.2012.08.002 38

Dupuy, Thyroid hormone biosynthesis and release

In normal cells and tissues, more than 90% of glutathione is reduced, and the remainder is the disulfide GSSG of oxidized glutathione

This process can be initiated by iron-catalyzed Fenton chemistry, in which hydroxyl radicals (OH) generated from H 2 O 2 trigger a self-propagating lipid peroxidation chain reaction