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4 Gut microbiota and inflammatory signaling pathways in depression 4.1 MAPK signaling pathway MAPKs are important intracellular signaling molecules and mainly include extracellular signal-regulated kinases (ERKs), Jun N-terminal kinases (JNKs), and p38 kinases ( The MAPK pathway can be activated by various stimuli, including stress and inflammation

Dose and frequency depend on your B12 levels and underlying condition
