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The B12 intravenous dose is usually the same as the intramuscular dose, from 1000 mcg to 2500 mcg per infusion

This promoter is active in neural crest cells, and driving MYCN overexpression in these progenitor cells of NB causes the animals (Th- MYCN ) to develop tumors that closely resemble human NB ( in vitro

However, current data indicate that the optimum obtainable neurologic response may be expected with a dosage of vitamin B12 sufficient to produce good hematologic response